Synaptic receptor trafficking: The lateral point of view
نویسندگان
چکیده
منابع مشابه
AMPA receptor trafficking and synaptic plasticity.
Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA receptor trafficking in LTP and LTD, focu...
متن کاملAnalysis of Ampa Receptor Trafficking Ampa Receptor Trafficking: a Mechanism of Excitatory Synaptic Plasticity
Glutamate is the main excitatory neurotransmitter in the cortex and the tetrameric AMPA receptors (AMPARs) mediate the fast excitatory component of postsynaptic potential. Trafficking of AMPARs has been implicated in synaptic plasticity regulation, including long-term potentiation, long-term depression, and synaptic scaling. Two proteins, GRIP for stabilization at the synapse and PICK for inter...
متن کاملAMPA Receptor Trafficking and the Control of Synaptic Transmission
meable to calcium and that controls synaptic plasticity. Activation of NMDA receptors leads to the appearance of functional AMPA receptors (“unsilencing”) in previously silent synapses, thereby potentiating synaptic transmission (Malenka and Nicoll, 1999; Malinow et al., Morgan Sheng1,2 and Sang Hyoung Lee2 Department of Neurobiology and Howard Hughes Medical Institute Massachusetts General Hos...
متن کاملThe cell biology of synaptic plasticity: AMPA receptor trafficking.
The cellular processes that govern neuronal function are highly complex, with many basic cell biological pathways uniquely adapted to perform the elaborate information processing achieved by the brain. This is particularly evident in the trafficking and regulation of membrane proteins to and from synapses, which can be a long distance away from the cell body and number in the thousands. The reg...
متن کاملSynaptic metaplasticity through NMDA receptor lateral diffusion.
Lateral diffusion of glutamate receptors was proposed as a mechanism for regulating receptor numbers at synapses and affecting synaptic functions, especially the efficiency of synaptic transmission. However, a direct link between receptor lateral diffusion and change in synaptic function has not yet been established. In the present study, we demonstrated NMDA receptor (NMDAR) lateral diffusion ...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2009
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2008.01.075